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The principal cytochrome P450 isoenzyme involved appears to get CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Roughly eighty five% of an oral dose appears in the urine within just 24 hrs of administration, most as the glucuronide conjugate, with compact quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity information.

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